The movie is the sequel to Ang Tangning Ina (The Only Mom) where comedienne Ai-Ai De las Alas reprises her role as Ina Montecillo, the hard-working mother of twelve who gets in to different odd jobs to support her family. Also back is the funny Eugene Domingo as Rowena, the best friend who manages to get herself entangled with Ina in funny and wacky situations.

The film is about the continuing story Ina and how she accepts different odd jobs (from being a stunt double, a waitress, a college student, and business owner) to get the money needed for their family's daily living. Her new adventure brings her to a new arena-- the political scene as she becomes the president of the Philippines by a twist of fate. The film's humor centers on her national policies that seem to defy logic and her interaction with Rowena.