One True Love is a GMA films and Regal Entertainment starring Dingdong Dantes, Marian Rivera, and Iza Calzado star in the romantic movie. The movie is about a medical intern Migs (played by Dingdong) about to get married to a nurse named Joy (played by Marian). Days before wedding, his first love Bella (Iza) returns to the Philippines. Bella is still single and still in love with Migs determined to fight for her love.

Migs then figures into an accident and develops lacunar amnesia and he forgets about his relationship with Joy, leaving him with memories of Bella. Joy finds it difficult to accept what happened but vows to make Mig's heart remember what his mind cannot.